YO-01027

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YO-01027 (Dibenzazepine) 是一种二肽 γ-分泌酶抑制剂，对于 APPL 和 Notch 裂解的 IC50 分别为 2.6 nM 和 2.9 nM。

YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.

YO-01027 (0.25-10 μM, during 1-18 days) promotes iPSC generation from human neonatal keratinocytes.YO-01027 (2 μM, 3 days) does not affect p53 activity in OCT4, SOX2-transduced human keratinocytes.YO-01027 (10 μM, 3 days) promotes the proliferation of supporting cells (SCs) in cultured mouse cochleae.YO-01027 (10 μM, 3 days) generates new hair cell (HCs) and increases the HCs number in neonatal mouse cochleae.

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Dibenzazepine

Neuroscience

Gamma-secretase

γ secretase (APPL)| γ secretase(Notch)

Metabolic Disease

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209984-56-5

463.48

C26H23F2N3O3

>98% (HPLC)

DMSO:92 mg/mL (198.49 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

C[C@H](NC(CC1=CC(F)=CC(F)=C1)=O)C(N[C@@H]2C(N(C)C3=CC=CC=C3C4=CC=CC=C24)=O)=O

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

(-20℃)

With Ice Pack

≥ 2 years